Discovery of Splendid Gift, Avermectin, and Studies on Avermectin Biosynthesis
نویسندگان
چکیده
منابع مشابه
Biocatalytic conversion of avermectin into 4''-oxo-avermectin: discovery, characterization, heterologous expression and specificity improvement of the cytochrome P450 enzyme.
4''-Oxo-avermectin is a key intermediate in the manufacture of the insecticide emamectin benzoate from the natural product avermectin. Seventeen Streptomyces strains with the ability to oxidize avermectin to 4''-oxo-avermectin in a regioselective manner have been discovered, and the enzymes responsible for this reaction were found to be CYPs (cytochrome P450 mono-oxygenases). The genes for thes...
متن کاملSafety of moxidectin in avermectin-sensitive collies.
OBJECTIVE To evaluate the safety of moxidectin administration at doses of 30, 60, and 90 microg/kg of body weight (10, 20, and 30 times the manufacturer's recommended dose) in avermectin-sensitive Collies. ANIMALS 24 Collies. PROCEDURE Collies with mild to severe reactions to ivermectin challenge (120 mg/kg; 20 times the recommended dose for heartworm prevention) were used. Six replicates o...
متن کاملControl of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component.
I. Biosynthesis of Avermectins A. Incorporation of Labeled Precursors B. Biosynthetically Blocked Mutants and Characteristics of Each Step in Avermectin Biosynthetic Pathway 1. aveA {aveAI and aveAIh step for polyketide synthase) 2. aveB (step for glycosylation) 3. aveC (step for C22~23-dehydration) 4. aveD (step for C5 O-methylation) 5. aveE (step for furan ring formation at C6 to C8a) 6. aveF...
متن کاملScientific Background Avermectin and Artemisinin - Revolutionary Therapies against Parasitic Diseases
The 2015 Nobel Prize in Physiology or Medicine is awarded with one half jointly to Dr. William C. Campbell and Professor Satoshi Ōmura for their discoveries concerning a novel therapy against infections caused by roundworm parasites and the other half to Professor Youyou Tu for her discoveries concerning a novel therapy against Malaria. Parasitic diseases have long plagued humankind and constit...
متن کاملSAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development
Avermectins are useful anthelmintic antibiotics produced by Streptomyces avermitilis. We demonstrated that a novel AraC-family transcriptional regulator in this species, SAV742, is a global regulator that negatively controls avermectin biosynthesis and cell growth, but positively controls morphological differentiation. Deletion of its gene, sav_742, increased avermectin production and dry cell ...
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ژورنال
عنوان ژورنال: TRENDS IN THE SCIENCES
سال: 2016
ISSN: 1342-3363,1884-7080
DOI: 10.5363/tits.21.2_13